血小板反应蛋白-1和血小板活化因子在川崎病中的变化及意义

目的: 探讨川崎病患儿血浆血小板反应蛋白 1(thrombospondin 1，TSP 1)、血小板活化因子(platelet activating factor，PAF)的变化及意义。方法: 收集川崎病患儿53例,按心脏超声检查显示的冠状动脉内径，分成冠状动脉损伤(CAL)组32例和非冠状动脉损伤(NCAL)组21例，均于急性期及恢复期采用ELISA法检测血浆TSP 1、PAF含量。另以20例健康儿童作为对照组。结果： 川崎病组患儿急性期血浆TSP 1浓度明显高于恢复期和对照组(P均＜0.05)，而恢复期与对照组间差异无统计学意义(P＞0.05)。血浆PAF含量在川崎病组急性期、恢复期均显著高于对照组(P均＜0.05);急性期CAL组PAF含量显著高于NCAL组(P＜0.05)。 结论： 川畸病患儿血浆TSP 1和PAF含量与急性期炎症反应相关，PAF可作为预测冠状动脉早期损伤的实验室指标。

Changes of plasma thrombospondin-1 and platelet activating factor in Kawasaki disease and their clinical significance

Objective: To investigate the level and significance of plasma thrombospondin 1(TSP 1) and the platelet activating factor(PAF) in children with Kawasaki disease (KD). Methods: A total of 53 children with KD were enrolled in this study, including 32 children with coronary artery lesion(CAL) and 21 children with non coronary artery lesion (NCAL).The level of plasma TSP 1 and PAF was detected by ELISA assay. Twenty normal children were collected as the control group. Results: Plasma TSP 1 in acute phase of KD group increased significantly than that of the control group and the convalescence of KD group(P＜0.05)，while there was no difference between the convalescence of KD group and the control group(P>0.05).Compared with the control group, the level of plasma PAF increased obviously both in acute phase of KD group and in the convalescence of KD group(P＜0.05).The level of plasma PAF in CAL group was significantly higher than that of NCAL group(P<0.05) during the acute phase group. Conclusion: The content of plasma TSP 1 and PAF were associated with inflammation of KD in acute stage. The level of plasma PAF may be a biochemical index to predict the early coronary artery lesion in KD.