2型糖尿病患者颈动脉内中膜厚度与低度白蛋白尿的相关性

目的: 探讨2型糖尿病（type 2 diabetes mellitus,T2DM）患者颈动脉内中膜厚度（carotid intima madia thickness,CIMT）与低度白蛋白尿的相关性。方法: 选择T2DM患者460例，检测CIMT和尿白蛋白/肌酐比值（urinary albumin to creatinine ratio，UACR）。根据UACR四分位切点将全部患者分为4组，分别为0＜Q1＜7.06 mg/g（n=112），7.06≤Q2＜8.91 mg/g（n=118），8.91≤Q3＜12.10 mg/g（n=115），12.10≤Q4＜30.0 mg/g（n=115）。收集4组患者的一般资料，采用Logistic回归分析CIMT和UACR的相关性。结果： Q1-Q4组CIMT增厚的发生率分别为30.36%、38.14%、45.22%、53.91%，且CIMT与UACR呈正相关（r=0.300，P<0.01）。Logistic回归分析显示UACR与CIMT增厚发生率相关(OR：1.166，95%CI：1.080～1.259，P<0.01)。 结论： 随着UACR升高，CIMT增加。UACR是T2DM患者CIMT增厚的危险因素。

Association of carotid intima-media thickness and low-grade albuminuria in patients with type 2 diabetes

Objective: To investigate the relationship between carotid intima media thickness(CIMT) and low grade albuminuria in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 460 inpatients with T2DM were recruited. The CIMT and urinary albumin to creatinine ratio(UACR) were measured. Based on the quartile of UACR, all patients were divided into four groups: 0＜Q1＜7.06 mg/g(n=112),7.06≤Q2＜8.91 mg/g(n=118),8.91≤Q3＜12.10 mg/g(n=115),12.10≤Q4＜30.0 mg/g(n=115).Baseline data and clinical data of each patient was collected. The relationship between CIMT and UACR were tested with Logistic regression. Results: The prevalence of CIMT was 30.36% in Q1, 38.14% in Q2, 45.22% in Q3 and 53.91% in Q4, respectively. And CIMT was positively correlated with UACR（r=0.300,P<0.01）.Logistic regression revealed that UACR had correlation with elevated CIMT(OR:1.166, 95%CI: 1.080-1.259, P<0.01). Conclusion: The prevalence of CIMT in T2DM patients increased with the rise of UACR. UACR is risk factor for T2DM patients with elevated CIMT.