核黄素磷酸钠联合干扰素治疗小儿疱疹性咽峡炎的 疗效观察

目的 观察核黄素磷酸钠联合干扰素治疗小儿疱疹性咽峡炎的临床疗效。方法 选取2016年5月~2017年10月在我院治疗的72例小儿疱疹性咽峡炎患儿临床资料为研究对象，将其随机分为对照组和观察组，每组36例。对照组采用干扰素治疗，观察组在对照组基础上联合应用核黄素磷酸钠治疗，对比两组患者治疗总有效率、体征平均消退时间、住院时间和不良反应情况。结果 观察组治疗有效率为91.67%，高于对照组的77.78%，差异具有统计学意义（P＜0.05）；观察组患儿体征平均消退时间为（2.88±1.20）d，住院时间为（5.87±1.66）d，分别短于对照组的（3.14±1.11）d，（7.53±0.95）d，差异有统计学意义（P＜0.05）；观察组不良反应发生率为8.33%，低于对照组的22.22%，差异有统计学意义（P＜0.05）。结论 核黄素磷酸钠联合干扰素治疗小儿疱疹性咽峡炎可快速改善患儿临床症状，且临床不良反应少，具有临床应用和推广的重要价值。

Therapeutic Effect of Riboflavin Sodium Phosphate Combined with Interferon on Pediatric Herpangina

Abstract:Objective To observe the clinical efficacy of riboflavin sodium phosphate combined with interferon in the treatment of pediatric herpangina.Methods The clinical data of 72 children with herpes isthmus treated in our hospital from May 2016 to October 2017 were randomly divided into control group(n=36)and observation group(n=36).The control group was treated with interferon,the observation group was treated with riboflavin sodium phosphate on the basis of the control group,and the total effective rate,mean regression time of signs,hospitalization time and adverse reactions were compared between the two groups.Results The effective rate was 91.67% in the observation group,which was 77.78% higher than that in the control group,the difference was statistically significant(P<0.05).The mean extinction time of the observation group was (2.88±1.20)d,and the length of hospital stay was(5.87±1.66) d,which was shorter than that of the control group (3.14±1.11)d,(7.53±0.95)d,the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 8.33%,which was lower than the 22.22% of the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of riboflavin sodium phosphate and interferon in the treatment of pediatric herpangina can rapidly improve the clinical symptoms of children,and there are few clinical adverse reactions.It has important clinical application and promotion value.