胰高血糖素样肽-2对放射损伤小鼠肠上皮恢复的影响

目的：探讨胰高血糖素样肽－2对放射损伤小鼠肠上恢复的影响。方法：昆明种小鼠经8Gy^60 Co γ射线一次性全身照射后随机分为放射损伤对照组和胰高血糖素样肽－2处理组，检测小肠粘膜组织DNA和蛋白含量，光镜和扫描电镜观察肠上皮形态结构变化。结果：放射损伤小肠粘膜组织DNA和蛋白含量降低，肠绒毛高度下降、数量减少，部分绒毛顶端有糜烂缺损；胰高血糖素样肽－2处理可使肠粘膜组织DNA和蛋白含量降低，肠绒毛增长、数量增多，糜烂发生不明显。结论：胰高血糖素样肽－2可促进放射损伤小鼠肠上皮的恢复。

Effects of glucagon-like peptide 2 on recovery of small intestinal epithelia from radiation injury in mice

Objective To investigate the effects of glucagon like peptide 2 (GLP 2) on recovery of small intestinal epithelia from radiation injury in mice. Methods Mice received a single 8 Gy dose of total body irradiation from 60 Co gamma ray followed by treatment with GLP 2 or vehicle. DNA and protein content in small intestinal mucosa were measured, and small intestine was processed for histological examination with light microscope and scanning electron microscope. Results Small intestinal mucosal DNA and protein content, villus height, and villus number significantly decreased in irradiated mice, partial villus tips were ulcerated. GLP 2 administration caused increase in DNA and protein content, villus height, and villus number as compared with irradiated control group. Meanwhile, the villus tips were lack of ulceration. Conclusion GLP 2 can promote recovery of small intestinal epithelia from radiation injury in mice.