促红细胞生成素不同给药次数对防治早产儿贫血的临床研究

目的：探讨促红细胞生成素（EPO）防治早产儿贫血的最佳治疗方案。方法：将78例早产儿随机分为对照组,治疗1组和治疗2组,对照组口服维生素,治疗1组用EPO按750IU/（kg·周）,分4次皮下注射,治疗2组用EPO按750IU/（kg·周）,分2次皮下注射,动态观察患者的血色素、网织红细胞比例、血清铁蛋白变化,记录输血次数,相关数据进行统计学处理。结果：对照组与治疗组（治疗1组＋治疗2组）比较,血红蛋白、网织红细胞比例、输血次数均存在显著差异,未见明显毒副作用,说明EPO对防治早产儿贫血安全、有效;治疗1组与治疗2组比较,血红蛋白、网织红细胞比例在治疗后期及输血次数的差异具有显著性,治疗1组优于治疗2组。结论：促红细胞生成素（EPO）在大剂量、早治疗的前提下,分多次给药对防治早产儿贫血疗效更好。

Erythropoietin in the prevention of the number of different administration clinical study of anemia in premature children

Objective：To investigate erythropoietin （EPO） prevention and treatment of anemia in premature children the best treatment regimens. Methods：78 patients with premature children will be randomly divided into control group,treatment group 1 and treatment 2 group and the control group was treated with vitamins,treatment group 1 with EPO by 750 IU/（kg·weeks）,4 times subcutaneously,treatment 2 group with EPO by 750 IU/（kg·weeks）,sub-2 subcutaneously,dynamic observation of hemoglobin,reticulocyte percentage,serum ferritin changes,record the number of blood transfusion,the data were analyzed statistically. Results：In control group and treatment group（treatment group 1＋treatment 2 group）,hemoglobin,reticulocyte percentage,the number of blood transfusion were significant differences,no significant side effects,indicating EPO on the prevention and treatment of anemia in premature children was safe and effective; treatment 1 comparison group and treatment group 2,hemoglobin,reticulocyte percentage and blood transfusion in the treatment of late the number of significant differences in the treatment group 1 than group 2 treatment. Conclusion：Erythropoietin（EPO） in large doses,early treatment of the subject,the prevention of preterm delivery in multiple child anemia better.