结肠直肠肿瘤手术单剂预防性抗生素应用

目的探讨结肠直肠肿瘤择期手术单剂预防性应用抗生素的效果。方法回顾性分析我院2001年1月～2006年12月结肠直肠肿瘤择期手术187例的临床资料。术前单剂预防性应用抗生素,感染高危病例联合应用粒细胞集落刺激因子,统计术后切口感染发生率和腹腔感染发生率。结果本组术后发生切口感染6例,感染率为3.2%;腹腔感染2例,感染率为1.1%。结论结肠直肠肿瘤择期手术前单剂预防性合理应用抗生素,可有效预防术后切口感染和腹腔感染。对于感染高危病例,联合应用G-CSF和单剂抗生素预防感染,效果确切可靠。

Preoperative prophylactic administration of single dose antibiotics for patients with colorectal carcinoma

Objective To explore the effect of preoperative prophylactic administration of antibiotics for elective operative patients with colorectal carcinoma.Methods The clinical data of the elective operative patients with colorectal carcinoma from Jan. 2001 to Dec. 2006 were retrospectively analyzed.Before operation, single dose antibiotics were used and for those patients with high risk of infection recombinant human granulocyte colony-stimulating factor was administered.The incidence of postoperative wound and intraabdominal infection was analyzed.Results In the 187 cases,postoperative wound infection occurred in 6 cases(3.2%)and intraabdominal infection occurred in 2 cases(1.1%).Conclusion For elective operative patients with colorectal carcinoma,preoperative prophylactic administration of single dose antibiotics is effective,and for the patients with high risk of infection,the combined use of recombinant human granulocyte colony-stimulating factor is reliable.