脱氢紫堇碱对心血管系统的药理作用

延胡索治疗冠心病的药理研究已有报道,几年来临床用其醇浸膏制剂治疗心绞痛、冠不全、急慢性心肌梗塞有效,还发现其中脱氢紫堇碱(DHC)有明显活性,但报道除治疗胃溃疡外,研究甚少。为此进行本工作,并与四氢巴马丁(THP)比较。

PHARMACOLOGICAL ACTIONS OF DEHYDROCORYDALINE CARDIOVASCULAR SYSTEM

The pharmacological actions of dehydrocorydaline (DHC) isolated from Chinese medicine Yan Husuo (Corydalis Yanhusuo) on cardiovascular system have been observed and compared with those of tetrahydropalmatine (THP).DHC was shown to be more active than THP in increasing the tolerance of mice to monobaric and hypobaric hypoxia.In anesthetized open-chest cats, the coronary venous flow was enhanced by iv DHC 1 mg/kg, but the heart rate was slowed slightly, whereas THP only exhibited a negative effect. After administration of DHC, the myocardial uptake of ~(86)Rb in mice was increased. The protective actions on change of ECG induced by pitutrin, and on experimental myocardial necrosis induced by isoproterenol were observed. THP, however, exerted no marked effect.Both DHC and THP showed similar sedative and anticonvulsive effects on CNS, but the action of DHC was weaker and more lasting.From these findings, it appears that DHC is one of the active principles of Yanhusuo for the treatment of coronary heart disease.