Quinaldopeptin, a novel antibiotic of the quinomycin family |
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Authors: | S Toda K Sugawara Y Nishiyama M Ohbayashi N Ohkusa H Yamamoto M Konishi T Oki |
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Affiliation: | Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan. |
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Abstract: | Quinaldopeptin, a new type of quinomycin antibiotic, was isolated from the culture of Streptoverticillium album strain Q132-6. The antibiotic exhibited strong in vitro antimicrobial and cytotoxic activity and significantly prolonged the survival time of mice inoculated with a murine tumor. Quinaldopeptin is a symmetric cyclic peptide linked only by peptide bonds and differs from known antibiotics of the quinomycin family by the lack of ester linkage. |
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