| 吸入麻醉药镇痛、催眠作用与GABA_A受体的关系 |
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| 引用本文： | 颜梅,戴体俊. 吸入麻醉药镇痛、催眠作用与GABA_A受体的关系[J]. 中国药理学通报, 2004, 20(5): 521-523 |
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| 作者姓名： | 颜梅 戴体俊 |
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| 作者单位： | 1. 徐州医学院药理学教研室,徐州,221002
2. 徐州医学院麻醉学系,徐州,221002 |
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| 基金项目： | 国家自然科学基金，江苏省自然科学基金 |
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| 摘 要： | 目的 分析吸入麻醉药安氟醚、异氟醚和七氟醚催眠、镇痛作用与GABAA 受体的关系。方法 建立小鼠催眠、镇痛模型后 ,在小鼠催醒、热板、扭体实验中 ,分别观察用药后小鼠翻正反射消失持续时间、痛阈或扭体次数的变化。结果 一叶秋碱和荷包牡丹碱对上述 3种吸入麻醉药的催眠、镇痛作用的影响均无显著性 (P >0 0 5 )。结论 GABAA 受体并非安氟醚、异氟醚和七氟醚催眠、镇痛作用的主要靶位
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| 关 键 词： | 吸入麻醉药 催眠 镇痛 一叶秋碱 荷包牡丹碱 GABAA受体 |
| 文章编号： | 1001-1978(2004)05-0521-03 |
| 修稿时间： | 2003-10-04 |
The relationship between the analgesic and hypnotic effects of volatile anesthetic and GABAA receptor |
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| YAN Mei,DAI Ti-Jun. The relationship between the analgesic and hypnotic effects of volatile anesthetic and GABAA receptor[J]. Chinese Pharmacological Bulletin, 2004, 20(5): 521-523 |
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| Authors: | YAN Mei DAI Ti-Jun |
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| Affiliation: | YAN Mei,DAI Ti-Jun 1 |
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| Abstract: | AIM To study the relationship between the analgesic and hypnotic effects of enflurane, isoflurane and sevoflurane and GABA A receptor. METHODS After having established the mice model of analgesics and hypnotics, we injected the mice with GABA A-receptor antagonist and observed changes of sleep time using awaken test, pain threshold hot-plate test and writhing times writhing test. RESULT Securinine and bicuculline had no distinctive effects to the three volatile anesthetics mentioned above (P>0.05). CONCLUSION GABA A receptor may not be the major target of enflurane, isoflurane and sevoflurane. |
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| Keywords: | volatile anesthetic hypnotics analgesics securinine bicuculline GABA A receptor |
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