| NT—3、NT—4和BDNF在面神经逆行转运的动力学比较 |
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| 摘 要： |
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| 关 键 词： | 神经营养素3 神经营养素4 脑源性神经营养素 逆行转运动学 面神经 |
A comparison of the kinetic characters of NT-3, NT-4 and BDNF retrogradely transported in facial nerve] |
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| Y Li,Z Chen,Q Wang,Z Liang,A Kuang,G He,B Gao,D Lin. A comparison of the kinetic characters of NT-3, NT-4 and BDNF retrogradely transported in facial nerve][J]. Journal of West China University of Medical Sciences, 2001, 32(4): 535-537 |
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| Authors: | Y Li Z Chen Q Wang Z Liang A Kuang G He B Gao D Lin |
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| Affiliation: | Department of Nuclear Medicine, First Affiliated Hospital, WCUMS, Chengdu, 610041 China. |
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| Abstract: | OBJECTIVE: To compare the kinetic characters of retrograde transport of neurotrophin-3 (NT-3), neurotrophin-4 (NT-4) and brain-derived neurotrophin factor (BDNF) in facial nerve. METHODS: Radioactive tracer technique was used. After one lateral facial nerve trunk of adult rabbit was transected, a silicone chamber was inserted between the stumps, and 3.7 MBq of 125I-NT-3 or 125I-NT-4 or 125I-BDNF or 125I-HSA was administered into the chamber. At different time-points after injection, the facial nerve trunk and facial nerve motor neurone of brain-stem were collected and the uptake rates were measured. The kinetic parameters of each labeled compound were calculated using 3P87 program of kinetics. RESULTS: The transport amount of neurotrophin retrogradely transported by facial nerve is NT-3 > BDNF > NT-4 (P < 0.05), the transport rate is NT-4 > NT-3 > BDNF (P < 0.05). CONCLUSION: The findings could serve as the kinetic characters of retrograde transport of neurotrophins. |
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