骨桥蛋白与感染性疾病

骨桥蛋白是由活化巨噬细胞、白细胞和活化的T细胞分泌,广泛分布于细胞外液和矿化组织的细胞外基质中,具有免疫调节等多种生物功能的分泌性磷酸化糖蛋白.在宿主感染结核杆菌、真菌、细菌等病原体时,启动机体免疫抵抗病原体,发挥抗炎作用.随后可能发挥致炎作用,具有免疫双向调节作用.它的表达可能反映机体感染时的免疫反应水平和炎症程度.在微生物广泛耐药的今天,它的适当表达和应用可能为临床感染性疾病治疗开辟一条新的途径.

Osteopontin and infectious diseases

Osteopontin(OPN)is a secreted phosphorylation glycoprotein,which is secreted by activated macrophage,leucocyte and activated T lymphocyte.OPN universally distributes over extracellular fluid and extracellular matrix of mineralized tissues and has multiple biological functions such as immunoloregulation etc.When host is infected with Mycobacterium tuberculosis,eumycete and bacterium,OPN can switch on host immunity to resist pathogens and enduce an anti-inflammatory action,but it also can bring into phlegmonosis soon after,so OPN has two-way accommodation.The expression level of OPN can reflect immunereaction level and inflammation level when host iS infected.Today when the drug resistance of microorganism is widespreaded,the appropriate expression and application of OPN can open up an original way for the treatment of clinical infeetious diseases.