Anti-allergic prenylated flavonoids from the roots of Sophora flavescens |
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Authors: | Quan Wenying Lee Hee Ju Kim Chul Young Noh Chu Won Um Byung Hun Oak Min-Ho Kim Kyeong-Man |
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Institution: | Department of Pharmacology, Drug Development Research Center, College of Pharmacy, Chonnam National University, Kwang-Ju, Korea. |
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Abstract: | The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids ( 1 - 8) responsible for the IN VITRO anti-allergic activity. Among them, kushenol N ( 3), sophoraflavanone G ( 6), and leachianone A ( 7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC (50) values ranging from 15 to 30 muM. |
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