| Ge-132对荷瘤小鼠肿瘤生长及免疫功能的影响 |
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| 引用本文： | 司传平,刘宁,赵冲,于江,朱怀甫. Ge-132对荷瘤小鼠肿瘤生长及免疫功能的影响[J]. 中国免疫学杂志, 1999, 15(6): 271-272 |
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| 作者姓名： | 司传平 刘宁 赵冲 于江 朱怀甫 |
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| 作者单位： | 1. 济宁医学院免疫学教研室,济宁272113
2. 中国科学院动物研究所 |
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| 摘 要： | 目的：探讨Ｇｅ－１３２对荷瘤小鼠的抑瘤作用及其抗肿瘤免疫效应机制。方法；以荷瘤小鼠为模型，采用腹腔注射Ｇｅ－１３２「１００，３００ｍｇ／（ｋｇ．ｄ）」，连续注射１４ｄ，观察肿瘤生长及Ｇｅ－１３２对小鼠免疫功能的影响。结果；Ｇｅ－１３２能显著抑制荷瘤小鼠Ｓ１８０肉瘤的生长，抑瘤率达５５％。
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| 关 键 词： | Ge－132 荷瘤小鼠 细胞免疫 NK活性 LAK活性 |
Effect of Ge-132 on the tumor growth and immunefunctions in tumor-bearing mice |
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| SI ChuanPing,LIU Ning,ZHAO Chong et al. Effect of Ge-132 on the tumor growth and immunefunctions in tumor-bearing mice[J]. Chinese Journal of Immunology, 1999, 15(6): 271-272 |
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| Authors: | SI ChuanPing LIU Ning ZHAO Chong et al |
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| Affiliation: | SI ChuanPing,LIU Ning,ZHAO Chong et al.Department of Immunology,Jining Medical College,Jining 272113 |
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| Abstract: | Objective: In order to investigate the antitumor effect of Ge132 and its immunological mechanisms. Methods: The tumor-bearing mice were treated with Ge132(100mg/kgd and 300mg/kgd ) and 14 days later to observe the effect of Ge132 on the tumor growth and the immunological functions in tumorbearing mice. Results: Ge132 inhibited the growth of S180 sarcoma significantly and promote the lymphocytic proliferation and IL2 producing ability of spleen cells in S180bearing mice. Ge132 enhanced significantly the activities of NK cells and LAK cells in tumorbearing mice. Conclusion: These results suggested that Ge132 could obviously inhibit the growth of tumor in mice and the antitumor effect of Ge132 might be mediated by inducing the antitumor immunity of the host. |
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| Keywords: | Ge132Tumorbearing miceIL2NK activityLAK activity |
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