戈那瑞林(GnRH)在多囊卵巢综合征患者中的促排卵作用

目的:探讨国产戈那瑞林(GnRH)预防多囊卵巢综合征(PCOS)不孕患者中促排卵后卵巢过度刺激综合征(OHSS)发生的临床价值。方法:PCOS不孕患者14例,常规使用氯米氛和hMG/FSH促进卵泡发育,当卵泡直径≥18mm时给予戈那瑞林100μg(皮下注射)诱发排卵,指导当天同房;阴道超声证实排卵后给予黄体酮20mg/d肌注,16d后复诊。观察排卵率、妊娠率、OHSS和多胎妊娠的发生率。结果:排卵率85.7%,妊娠率50%,其中1例多胎妊娠出现中度OHSS,但无重度OHSS的发生。结论:戈那瑞林(GnRH)可降低PCOS患者诱发排卵时中、重度OHSS的发生。

Application of Gonadotropin-releasing Hormone Agonist for Triggering Ovulation in Infertile Polycystic Ovary Syndrome Patients

Objective:To determine the clinical value of gonadotrophin-releasing hormone(GnRH)as ovulation induction agents in patients with polycystic ovary syndrome(PCOS)for trying to reduce the rate of ovarian hyperstimulation syndrome(OHSS).Methods:Fourteen patients of infertile PCOS were given for triggering follicular final maturation and ovulation in patients with Φ≥18 mm of follicle.After ovulation by vaginal-ultrasound,progesterone injection was given 20 mg/d.Their outcomes and complications were analyzed,such as the rate of ovulation,pregnancy and OHSS.Results:After treatment with GnRH,the rate of ovulation was 85.7%,and 50% became pregnancy in which only one patient had multiple pregnancy who developed mode OHSS.No patient developed severe OHSS.Conclusion:GnRH may be an effective therapeutic tool in high risk OHSS with PCOS patients.