通冠胶囊影响动脉粥样硬化兔血管内皮功能的超声研究

目的：观察通冠胶囊对动脉粥样硬化（AS）兔血管内皮功能的影响，探讨通冠胶囊抗动脉粥样硬化的作用和可能机制。方法：健康雄性新西兰白兔36只，按随机数字表法分为空白对照组、高脂对照组、阿托伐他汀组、通冠胶囊大、中、小剂量组，每组6只，空白对照组喂基本饲料，其余各组采用免疫性内皮损伤合并高脂饲料诱导建立As兔模型，高脂对照组喂高脂饲料，阿托伐他汀组在高脂对照组的基础上加喂阿托伐他汀5mg／kg／d；通冠胶囊小、中、大剂量组在高脂对照组基础上分别加喂通冠胶囊3mg／kg／d、9mg／kg／d及15mg／kg／d，实验周期为6周，各组动物分别于2、6周末行内皮功能超声检测血管内皮舒张功能（FMD）、血管内皮非依赖性舒张功能（NMD）及血脂检测。结果：6周末，通冠胶囊大剂量组、阿托伐他汀组与高脂对照组之间FMD、NMD比较，差异均有显著性意义（P〈0.05）；通冠胶囊大剂量组NMD、FMD与阿托伐他汀组比较，差异无显著性意义（P〉0．05）。结论：通冠胶囊能显著改善动脉粥样硬化兔血管内皮功能，其具有不依赖阿托伐他汀的独立的改善血管内皮功能的作用，而且在改善NMD方面，通冠胶囊优于阿托伐他汀，

Ultrasound Research of Effect of Tongguan Capsule on Vascular Endothelial Function of Atherosclerotic Rabbits

Objective:To investigate the therapeutic effect and possible mechanism of Tongguan Capsule(TC) on atherosclerosis(AS) through observing the impact of TC on vascular endothelial function of AS rabbits.Methods:Thirty-six healthy male New Zealand white rabbits were randomly divided into blank control group,model group,atorvastatin group,and large-,medium-and small-dose TC groups,six rabbits in each group.The blank control group was fed with the routine forage,and the other groups were given immunity endothelia...