百令胶囊联合注射用细辛脑治疗慢性阻塞性肺疾病急性加重期的疗效观察

目的探讨百令胶囊联合注射用细辛脑治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床效果。方法选择泸州市人民医院2016年4月—2017年5月接收的AECOPD患者116例,随机分为对照组(58例)和治疗组(58例)。对照组静脉滴注注射用细辛脑,24 mg加入5%葡萄糖注射液250 m L,1次/d。治疗组在对照组的基础上口服百令胶囊,5粒/次,3次/d。两组患者连续治疗14 d。观察两组患者临床疗效,比较治疗前后两组患者呼吸困难评分(MMRC)、辅助呼吸肌动用评分、血气分析和肺功能。结果治疗后,对照组患者临床有效率为82.76%,显著低于治疗组的94.83%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者MMRC评分和辅助呼吸肌动用评分均显著低于治疗前(P0.05);且治疗组上述评分比对照组降低的更明显(P0.05)。治疗后,两组患者动脉血氧分压(p O2)、血氧饱和度(Sa O2)均显著高于治疗前,动脉血二氧化碳分压(p CO2)显著降低,同组比较差异具有统计学意义(P0.05);且治疗组血气分析指标改善更明显(P0.05)。治疗后,两组患者用力肺活量(FVC)、第1秒用力呼气量(FEV1)、FEV1占预计值百分比(FEV1%pred)、FEV1/FVC均显著高于治疗前(P0.05);且治疗组患者肺功能显著优于对照组(P0.05)。结论百令胶囊联合注射用细辛脑治疗AECOPD疗效显著,可明显改善血气分析和肺功能,具有一定的临床推广应用价值。

Clinical observation of Bailing Capsules combined with Asarone for injection in treatment of acute exacerbation of chronic obstructive pulmonary disease

Objective To evaluate the clinical effect of Bailing Capsules combined with Asarone for injection in treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Patients (116 cases) with AECOPD in Luzhou People''s Hospital from April 2016 to May 2017 were randomly divided into control (58 cases) and treatment (58 cases) groups. Patients in the control group were iv administered with Asarone for injection, 24 mg added into 5% glucose injection 250 mL, once daily. Patients in the treatment group were po administered with Bailing Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the MMRC scores, the activity of accessory respiratory muscles scores, blood gas analysis and pulmonary function in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 82.76%, which was significantly lower than 94.83% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the MMRC scores and the activity of accessory respiratory muscles scores in two groups were significantly decreased (P < 0.05), and these scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the pO₂ and SaO₂ in two groups were significantly increased, but pCO₂ was significantly decreased, and there were differences in the same group (P < 0.05). And the blood gas indexes in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the FVC, FEV1, FEV1% pred and FEV1/FVC in two groups were significantly increased (P < 0.05), and the pulmonary function in the treatment group were significantly better than that in the control group (P < 0.05). Conclusion Bailing Capsules combined with Asarone for injection has significant effect in treatment of AECOPD, and can significantly improve blood gas analysis and lung function, which has a certain clinical application value.