3种降压治疗方案的药物经济学评价

目的 应用药物经济学原理评价3种降压治疗方案，并找出最佳给药方案。方法 采用回顾性分析法，收集金华市中心医院120例高血压患者，分为3组，A组给予福辛普利钠片，B组给予缬沙坦胶囊，C组给予苯磺酸氨氯地平，疗程均为8周，观察患者的临床疗效并进行最小成本分析。结果 A、B、C 3组的有效率分别为90.7%、92.3%、92.1%，3组间无显著性差异（P>0.05）。3组的不良反应发生率分别为16.7%、7.7%、13.2%（P>0.05）。3组的人均总成本分别为287.3元、378.7元、320.4元（P<0.05）。结论 3组方案的疗效相似，从经济学角度来说，福辛普利钠（A组）的成本效果比最优。

Pharmacoeconomic evaluation on three different anti-hypertensive treatments

Objective To compare three different anti-hypertension therapeutic projects by pharmacoeconomic evaluation and to find out the best therapeutic project. Methods Retrospective study was used.120 patients with hypertension were randomly assigned to group A (fosinopril sodium),group B(valsartan),group C(amlodipine besylate tablet),the therapeutic effects were observed and were evaluated by cost minimization analysis. Results The total efficiency of A,B,C group were 90.7%, 92.3%, 92.1% (P>0.05) respectively. The incidence of adverse reaction were 16.7%,7.7%,13.2%(P>0.05) respectively. The costs were 287.3 yuan, 378.7 yuan and 320.4 yuan respectively. Conclution The effectiveness of the three groups was similar. In terms of pharmacoeconomics, group A was the best therapeutic project.