IGF-1 is associated with fetal growth and preterm delivery in type 1 diabetic pregnancy |
| |
Authors: | Finn Friis Lauszus Jens Fuglsang |
| |
Affiliation: | 1. Department of Gynecology and Obstetrics, Herning Hospital, Herning, Denmark and;2. Aarhus University Hospital, Aarhus, Denmark |
| |
Abstract: | Aim: No data on IGF-1 and either preterm or preeclampsia have been reported so far in diabetic pregnancies. We evaluated consecutive measurements of IGF-1 for preeclampsia, preterm delivery and birth weight in type 1 diabetic pregnancy.Setting: In an outpatient university clinic, 97 pregnant women were consecutively recruited for evaluation of indicators for deterioration of diabetes status and adverse perinatal outcome. At every visit, a blood sample for measurement of IGF-1 was drawn.Results: IGF-1 levels from week 14 to 32 was consistently lower in women who delivered preterm compared with women whose delivered after gestational week 36; the increase in 2nd and 3rd trimester was steeper in those delivering at term than in women delivering preterm (p?=?0.032). IGF-1 in preeclampsia did not show the same relation in diabetic women (p?=?0.74). The lowest tertile of birth weight ratio (0.8–1.2) was associated with lower IGF-1 from week 14 to 32 (p?=?0.047, adjusted for preterm delivery and preeclampsia).Conclusion: We found low IGF-1 levels associated with preterm delivery and low birth weight. |
| |
Keywords: | Birth weight IGF-1 preeclampsia preterm delivery type 1 diabetes mellitus |
|
|