进入高原前后急性高原病患者血浆血管内皮生长因子的变化

【目的】研究急进高原人群中急性高原病（acutemountainsickness，AMS）患者发病前后血浆VEGF的变化。【方法】采用ELISA方法检测40名AMS和38名AMS耐受者两组在平原及进入高原后血浆VEGF浓度的变化。【结果】AMS组血浆VEGF浓度从平原的（79．276±27．48）pg／ml降至高原的（55．58±20．19）pg／ml（P〈0．01），对照组血浆VEGF浓度从平原的（41．03±37．37）pg／ml降至高原的（16．98±11．61）pg／ml（P〈0．01），AMS组在平原及高原的血浆VEGF浓度均显著高于对照组（P〈0．05）。【结论]AMS患者在平原状态下（发病前）及高原状态下（发病后）浓度均显著高于耐受者；AMS患者及耐受者急进高原后其血浆VEGF均显著降低，耐受者VEGF降低幅度更为明显。

Changes of plasma VEGF in MAS patients before and after going to plateau

Objective]To study the changes of plasma VEGF level in before and after going to plateau, and discuss the effect of plasma VEGF in patients with acute mountain sickness before and after going to the plateau. Methods]40 cases were selected as AMS group and 38 cases as AMS tolerate group, levels of VEGF in AMS group and tolerate group were measured by ELISA method. Results ] Plasma of VEGF concentrations of AMS group from plain（79.276 ± 27.48） pg/m] down to the high ahitude （55.58 ± 20.19 ） pg/ml （P 〈 0.01）, plasma of VEGF concentration of tolerate group from （41.03 ± 37.37） pg/m] in the plain clown to the high altitude of （16.98 ± 11.61） pg/ml （P 〈 0.01）. Plasma of EGF AMS group in the plain and high altitude were significantly higher after going to plateau. Conclusions]VEGF is down-regulated in AMS group and tolerate group at high altitude,but VEGF level of AMS group still higher significantly than tolerate group not only at high altitude but also at sea level.