新生儿病理性黄疸的预防干预时间窗探讨

目的:探讨早期干预对新生儿病理性黄疸的预防效果。方法:对2012年3月至2014年12月分娩的302例足月新生儿脐静脉血进行肝功能检测,并分别在生后24 h、48 h及72 h给予脐血总胆红素浓度 >50.1μmol/L或脐血总胆汁酸测量值 >11.295μmol/L的新生儿进行提早干预治疗。结果:干预组新生儿病理性黄疸的发生率为23.65%,明显低于对照组的58.44%(P<0.01)。生后24 h干预组和生后48 h干预组及72 h干预组新生儿病理性黄疸发生率差异均无统计学意义(P>0.05)。结论:脐血总胆红素浓度>50.1μmol/L或脐血总胆汁酸测量值 >11.295μmol/L的新生儿于生后进行干预治疗能有效预防病理性黄疸,值得临床推广。

Investigation of the prevention and intervention time window in pathological jaundice newborn

Objective:To investigate the preventive effects of the early intervention in newborn pathological jaundice. Methods:The liver function data of umbilical venous blood in 302 full-term newborns were measured from March 2012 to December 2014. The early intervention treatment in newborns with total bilirubin higher than 50. 1 μmol/L or total bile acid higher than 11. 295 μmol/L in umbilical cord blood were implemented after 24 h,48 h and 72 h of birth. Results:The incidence of the newborn pathological jaundice in early intervention(23. 65%) was lower than that in the nonintervention newborn(58. 44%)(P<0. 01). The effects of 24 h,48 h and 72 h intervention group was not statistically significant(P>0. 05). Conclusions:The invention after of birth in newborns with total bilirubin higher than 50. 1 μmol/L or total bile acid higher than 11. 295 μmol/L in umbilical cord blood can effectively prevent the pathological jaundice,which is worthy of promotion in clinic.