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Radioembolization of the Spleen: A Revisited Approach for the Treatment of Malignant Lymphomatous Splenomegaly |
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| Authors: | Kristoff Muylle Jasmine Nguyen Alexandre de Wind Nathalie Meuleman Philippe Delatte Bruno Vanderlinden Martine Roelandts Anja Van der Stappen Dominique Bron Patrick Flamen |
| Affiliation: | 1. Department of Nuclear Medicine, Jules Bordet Institute, ULB, Héger Bordetstraat 1, 1000, Brussels, Belgium 2. Faculty of Medicine, VUB, Laarbeeklaan 103, 1000, Brussels, Belgium 3. Department of Haematology, Jules Bordet Institute, ULB, Héger Bordetstraat 1, 1000, Brussels, Belgium 4. Department of Anatomo-Pathology, Jules Bordet Institute, ULB, Héger Bordetstraat 1, 1000, Brussels, Belgium 5. Department of Interventional Radiology, UMC Sint-Pieter, Hoogstraat 322, 1000, Brussels, Belgium 6. Department of Radiophysics, Jules Bordet Institute, ULB, Héger Bordetstraat 1, 1000, Brussels, Belgium 7. Department of Radiotherapy, Jules Bordet Institute, ULB, Héger Bordetstraat 1, 1000, Brussels, Belgium 8. Department of Radiology, Jules Bordet Institute, ULB, Héger Bordetstraat 1, 1000, Brussels, Belgium |
| Abstract: | Intraarterial administration of 90Y microspheres to the spleen in patients with malignant lymphoma was mentioned once in the literature in 1973. This case study illustrates the potential indication of selective internal radiotherapy in a heavily pretreated patient with highly refractory disease with a marginal zone lymphoma in leukemic phase and symptomatic splenomegaly. We describe the clinical course of disease; the biological and clinical response to the treatment after radioembolization; and simulation and dosimetry by multimodal imaging via single-photon emission computed tomography and computed tomography. The advantages of radioembolization for the management of lymphomatous splenomegaly are discussed. |
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