Superinfection Exclusion in Mosquitoes and Its Potential as an Arbovirus Control Strategy |
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| Authors: | Mathilde Laureti Prasad N. Paradkar John K. Fazakerley Julio Rodriguez-Andres |
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| Affiliation: | 1.Peter Doherty Institute for Infection and Immunity and Faculty of Veterinary and Agricultural Sciences, University of Melbourne, VIC 3000 Melbourne, Australia; ;2.CSIRO Health & Biosecurity, Australian Centre for Diseases Preparedness, VIC 3220 Geelong, Australia; |
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| Abstract: | The continuing emergence of arbovirus disease outbreaks around the world, despite the use of vector control strategies, warrants the development of new strategies to reduce arbovirus transmission. Superinfection exclusion, a phenomenon whereby a primary virus infection prevents the replication of a second closely related virus, has potential to control arbovirus disease emergence and outbreaks. This phenomenon has been observed for many years in plants, insects and mammalian cells. In this review, we discuss the significance of identifying novel vector control strategies, summarize studies exploring arbovirus superinfection exclusion and consider the potential for this phenomenon to be the basis for novel arbovirus control strategies. |
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| Keywords: | superinfection exclusion arbovirus vector control |
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