Synthesis of isotopically labelled versions of adenosine agonist GR79236 |
| |
| Authors: | Alan H. Wadsworth John J. Newman Mark D. Wipperman Ian Fellows Derek R. Sutherland |
| |
| Affiliation: | Development Chemistry Department, Chemical Development Division, Glaxo Wellcome Research and Development, Stevenage, Hertfordshire SG1 2NY, UK |
| |
| Abstract: | Versions of adenosine receptor agonist GR79236 (1 ), labelled either with carbon-14 (9 ) at C-8 of the purine ring or with tritium (15 ) in the cyclopentyl ring, were prepared in overall yields of 64% and 25% respectively. A mass labelled [M+4] version (24 ) containing carbon-13, nitrogen-15, and deuterium was also prepared in 3% yield. Copyright © 2000 John Wiley & Sons, Ltd. |
| |
| Keywords: | adenosine agonist GR79236 N-nitration mass label radiolabel recycling HPLC |
|
|
