| 苯妥英锌抗脂质过氧化及对小鼠缺血心肌的保护作用 |
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| 引用本文： | 李悦山,张国昌.苯妥英锌抗脂质过氧化及对小鼠缺血心肌的保护作用[J].中国病理生理杂志,1995,11(1):30-33. |
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| 作者姓名： | 李悦山 张国昌 |
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| 作者单位： | 新疆石河子医学院病理生理教研室，石河子医学院病理教研室，石河子医学院药学系 |
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| 摘 要： | 本研究观察苯妥英锌（ＰＨＴＺ）对异丙肾上腺素（ＩＳＯ）引起小鼠急性心肌缺血的保护作用，并与苯妥英钠（ＰＨＴＳ）比较。结果发现，与对照组相比，缺血组血浆ＭＤＡ含量升高１８．２％（Ｐ〈０．０５）；红细胞ＳＯＤ活力降低２７．８％（Ｐ〈０．０１）；全血ＧＳＨ－Ｐｘ活力降低１７．６％（Ｐ〈０．０１），心肌组织出现明显缺血性损伤（Ｐ〈０．０１）。与缺血组相比，ＰＨＴＳ及ＰＨＴＺ组ＭＤＡ含量分别降低２６．３％（
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| 关 键 词： | 丙二醛 超氧化物歧化酶 苯妥英锌 心肌缺血 |
Anti-lipid peroxidation and protective effects of phenytoin zinc on mice ischemic myocardium |
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| Li Yue-Shan,Zhang Guo-Chang,et al.Anti-lipid peroxidation and protective effects of phenytoin zinc on mice ischemic myocardium[J].Chinese Journal of Pathophysiology,1995,11(1):30-33. |
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| Authors: | Li Yue-Shan Zhang Guo-Chang |
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| Institution: | Li Yue-Shan,Zhang Guo-Chang,et al Department of Pathophysiology,Shihezi Medical College Shihezi,Xinjiang |
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| Abstract: | The protective effects of phenytoin zinc(PHTZ )and pbenytoin sodium(PHTS)on ischemic myocardium were investigated on experimental myocardial infarction model induced by subcutaneous injection of isoproterenol ( ISO)into mice.The results showed that(1)The MDA cont ents were increased by 18.2%(P
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| Keywords: | Phenytoin Isoprotrenol Myocardial infarction Malondialdehyde Superoxide dismutase |
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