乳腺癌caspase-7、caspase-3、survivin的表达及与临床病理因素关系的探讨

目的:探讨乳腺癌中caspase-7、caspase-3、survivin的表达、与临床病理因素的关系及3者间表达强度的相关性。方法:免疫组织化学法检测caspase-7、caspase-3、survivin在45例乳腺癌标本中的表达,并分析其与临床病理因素的关系。结果:caspase-7、caspase-3、survivin表达阳性率分别为73.33%、82.22%、73.33%,3者在年龄、月经状态、淋巴结有无转移各组中阳性率无显著差异,P值均>0.05。3者表达强度与肿块大小、临床TNM分期、组织学分级间,仅见caspse-7表达强度与肿块大小呈负相关(r=-0.306,P=0.041),caspse-7与caspase-3表达强度呈正相关(r=0.307,P=0.040)。结论:caspse-7与肿瘤负荷有关,与caspase-3在乳腺癌细胞凋亡过程中可能起协同作用,survivin在乳腺癌中高表达,3者与临床病理因素的关系需进一步深入研究。

Expression of caspase-7, caspase -3, survivin in breast neoplasm and their relationship with clinicopathologic factors

Objective: To explore expression of caspase-7,caspase-3,survivin in breast neoplasm and their relationship with clinicopathologic factors.Methods: Their expression in 45 patients with breast neoplasm was examined by immunohistochemical staining.Their relationship with clinicopathologic factors was analyzed.Results: Expression of caspase-7,caspase-3,survivin were 73.33%,82.22%,73.33% respectively.No significance was seen in their rates of expression with age,menstrual status,axillary lymph node metastases(P>0.05).Expression of casspase-7 was positively related with expression of casspase-3(r=0.307,P=0.040) and negatively with tumor size(r=-0.306,P=0.041).Conclusion: Caspase-7 is correlated with cancer load,with caspase-3 in proapoptosis.There is over expression of survivin in breast neoplasm.It is necessary to study their relationship with clinicopathologic factors systematically.