Mururins A-C,three new lignoids from Brosimum acutifolium and their protein kinase inhibitory activity |
| |
Authors: | Takashima Junko Asano Shoichi Ohsaki Ayumi |
| |
Affiliation: | Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, Yokohama, Japan. Takashima.Junko@me.m-pharma.co.jp |
| |
Abstract: | Two new flavonolignans, mururins A and B ( 1 and 2), and a new lignan, mururin C ( 3), were isolated from the bark of Brosimum acutifolium Huber together with three known lignans. Their structures were elucidated by spectroscopic means and chemical modifications. They were tested for protein kinase A (PKA) and protein kinase C (PKC) inhibitory activity. Mururin A showed 3 % and 63 % inhibition to PKA and PKC, respectively, at 20 microM. Mururin B showed 58 % and 38 % inhibition, respectively. Mururin C did not have significant activity. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|