山药新木脂素成分的研究

自胡椒科(Piperaceae)植物山蒟(Piper hancei Maxim)的藤茎分离到三种木脂素类化合物,根据光谱(UV,IR,NMR和MS)及X-射线单晶衍射分析,化合物Ⅲ确定为新结构,(7S,8R,3′S)-1′-烯丙基-3′-甲氧基-7-(3,4-次甲二氧基苯基)-7,8,3′,6′-四氢-6′-氧苯并呋喃,命名为山蒟素(hancinone);化合物Ⅰ为海风藤酮(kadsurenone);化合物Ⅱ为denudatin B。后两种化合物首次从本植物中分离。山蒟民间草药,治疗风湿和关节炎。以血小板活化因子(PAF)受体结合实验及PAF血小板聚集实验测定,化合物Ⅰ的抑制作用最强,化合物Ⅱ明显减弱,而化合物Ⅲ无活性。

NEOLIGNANS FROM PIPER HANCEI MAXIM

Piper hancei Maxim, Family Piperaceae, has been used in Chinese folk medicine for the treatment of rheumatoid arthritis and asthma. A new neolignan, hancinone (Ⅲ) was isolated together with two known neolignans, kadsurenone (Ⅰ) and denudatin B (Ⅱ). The structure of hancinone (Ⅲ) was established as (7. S, 8 R, 3′S) -1′ - allyl-3′-methoxy-7- (3,4 -methylenedioxyphenyl) - 8 - methyl-7, 8, 3′, 6′-tetrahydro-6′-oxobenzofuran through interpretation of the spectral data (UV, IR, NMR and MS) and the results of a single crystal X-ray analysis.Kadsurenone (Ⅰ) and denudatin B (Ⅱ) were isolated for the first time from this plant.In the PAF receptor binding assay and the test of platelet aggregation, denudatin B (Ⅱ) was substantially less active than kadsurenone (Ⅰ), whereas hancinone (Ⅲ) showed' no PAF antagonistic activity.