Effect of treatments for head and neck cancer on sinus shadow on computed tomography |
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| Institution: | 1. Department of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan;2. Department of Otolaryngology, Tohoku Kosai Hospital, 2-3-11 Kokubun-cho, Aoba-ku, Sendai, Miyagi 980-0803, Japan;1. Department of Otorhinolaryngology - Head and Neck Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569-8686, Japan;2. Department of Pathology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569-8686, Japan;1. Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan;2. Department of Otorhinolaryngology, Ota Memorial Sleep Center, Kawasaki, Japan;3. Department of Otorhinolaryngology, Teikyo University Chiba Medical Center, Chiba, Japan;1. Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan;2. Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan;3. Department of Otorhinolaryngology, Toyota Kosei Hospital, Toyota, Japan;4. Department of Otorhinolaryngology, Anjo Kosei Hospital, Anjo, Japan;5. Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Science, Nagoya, Japan;6. Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan;1. Department of Otorhinolaryngology, Unit of Phoniatrics, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt;2. Department of Medical Studies, Faculty of Postgraduate Childhood Studies, Ain Shams University, Abbassia, Cairo, Egypt |
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| Abstract: | ObjectiveHead and neck surgeries may cause changes in the nasal airflow, and radiotherapy irreversibly damages paranasal sinus epithelial cells. Some chemotherapeutic drugs have been reported to negatively affect airway ciliary activity in mice, and chronic rhinosinusitis could be an adverse effect of head and neck cancer (HNC) treatment. To evaluate whether HNC treatment is a risk factor for developing sinonasal mucosal thickening that may reflect paranasal sinus inflammation, we compared pre- and post-treatment paranasal sinus computed tomography (CT) images of patients treated for HNC at a single university hospital.MethodsThe patients who received curative treatment for HNC (oral, pharyngeal, and laryngeal cancers) and started receiving first-line therapy between January 2015 and December 2019 were included. Data on age, sex, primary lesion, clinical stage, treatment, smoking history, drinking history, comorbidities (diabetes and chronic lung disease), and pre- and post-treatment (three months and one year after the final treatment) paranasal sinus CT images were analyzed from medical records. Pre- and post-treatment paranasal sinus CT images were scored using the Lund–Mackay (LM) staging system.ResultsIn total, 245 patients participated in this study. Three months after the final treatment, 80.4% of patients had no change in their total LM scores (p=0.621). Almost 80% of patients who underwent total laryngectomy also had no change in their total LM scores (p=0.833). One-third of patients with nasopharyngeal cancer (NPC) had worse LM scores after treatment (5/15), although no significant difference was observed (p=0.171). None of the various factors collected were significantly related to changes in LM scores three months after the completion of treatment. One year after the final treatment, 211 patients were included and no significant changes in the pre-and post-LM scores were observed in the same analyses, while changes in LM scores were significantly different between T categories (T1-2 vs. T3-4) (p=0.020).ConclusionWe found no significant changes in the LM scores after HNC treatment in all the patients, which implies that HNC treatment may not be an apparent risk factor for sinonasal mucosal inflammation. |
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