Human papillomavirus co-infection and survival in oral and oropharyngeal squamous cell carcinoma: A study in 235 Brazilian patients |
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| Affiliation: | 1. Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil;2. Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil;3. Centro Clínico de Cabeza y Cuello, Guatemala City, Guatemala;4. Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil;1. Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Nara, Japan;2. Department of Otolaryngology-Head and Neck Surgery, Nippon Life Hospital, Osaka, Japan;3. Department of Otolaryngology, Takai Hospital, Nara, Japan;1. Department of Otolaryngology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osakasayama-shi, Osaka 589-8511, Japan;2. Department of Otolaryngology, Head and Neck Surgery, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan;3. Department of Otolaryngology, Akasaka Toranomon Clinic, 1-8-1 Akasaka, Minato-ku, Tokyo, 107-0052, Japan;4. Department of Otorhinolaryngology and Department of Hearing Implant Sciences, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan;5. Department of Hearing Implant Sciences, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621 Japan;6. Department of Otolaryngology and Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan;1. HNO-Zentrum Rhein-Neckar, Mannheim, Germany;2. University hospital Mannheim, Department of Otorhinolaryngology, Mannheim, Germany;3. SLK-Kliniken Heilbronn, Department of Otorhinolaryngology, Klinikum am Gesundbrunnen, Heilbronn, Germany;4. University hospital Heidelberg, Department of Otorhinolaryngology, Heidelberg, Germany;1. Department of Otorhinolaringology, Audilogy, Firat University Faculty of Medicine, Elazig, Turkey;2. Department of Otorhinolaringology, Firat University Faculty of Medicine, Elazig, Turkey;3. Department of Otorhinolaringology, Ondokuz May?s University Faculty of Medicine, Samsun, Turkey;1. Digestive and Lifestyle Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan;2. Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan |
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| Abstract: | ObjectivesWhile unknown for oropharyngeal squamous cell carcinoma (OPSCC) and oral squamous cell carcinoma (OSCC), some studies assessing cervical carcinoma have shown that human papillomavirus (HPV) co-infection can be associated with its prognosis.MethodsThrough in situ hybridization (HPV and Epstein-Barr virus [EBV] probes) and immunohistochemistry (p16INK4a, cyclin D1, p53, and Ki-67 antibodies), 126 OPSCC and 109 OSCC samples were assessed.ResultsAll patients were EBV-negative. OPSCC (25%) showed a significant association with HPV compared to OSCC (11%). Almost all HPV-associated cases were p16INK4a-positive. Regarding OPSCC and OSCC, 23 and 7 cases were positive for high-risk HPV (HRHPV) only, 6 and 3 cases for low-risk HPV (LRHPV) only, and 3 and 2 cases for HRHPV/LRHPV, respectively. HPV-associated carcinomas showed a significantly higher proliferative index than HPV-unassociated carcinomas. Both carcinomas showed a similar overall survival rate, which was not affected by the HPV status. However, when comparing HPV-associated subgroups, patients with HRHPV/LRHPV-associated carcinomas showed worse survival.ConclusionLRHPV-associated and HRHPV/LRHPV-associated cases can also be detected when assessing OSCC and OPSCC. Further studies, especially in populations with a high prevalence of HPV-associated OPSCC, are necessary to understand the clinicopathological behavior of these neoplasm subgroups. |
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