Application of a direct pulp capping cement containing S-PRG filler |
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Authors: | Takahashi Yusuke Okamoto Motoki Komichi Shungo Imazato Satoshi Nakatsuka Toshiyuki Sakamoto Shuji Kimoto Katsuya Hayashi Mikako |
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Institution: | 1.Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8, Yamadaoka, Suita, Osaka, 565-0871, Japan ;2.Department of Biomaterials Science, Osaka University Graduate School of Dentistry, 1-8, Yamadaoka, Suita, Osaka, 565-0871, Japan ;3.Shofu Inc., 11, Kamitakamatsu-cho, Fukuine, Higashiyama-ku, Kyoto, 605-0983, Japan ; |
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Abstract: | Objectives To evaluate new pulp capping cements containing surface pre-reacted glass ionomer (S-PRG) filler and to investigate ion release kinetics and pH shift of eluates from the cement. Materials and methodsMolars of Wistar rats were directly pulp capped using three kinds of cement containing S-PRG filler and mineral tri-oxide aggregate (MTA) was used as a control. After 1, 2, or 4 weeks, histological evaluation was performed and differences of tertiary dentin formation were analyzed. Release of Sr2+, BO33−, SiO32−, Na+, and Al3+ ions was determined by inductively coupled plasma-atomic emission spectrometry, and F− ion release was measured using a fluoride ion selective electrode. The pH of the eluate from each cement after mixing was measured with a pH electrode. ResultsOne of S-PRG cements promoted tertiary dentin formation to the same extent as the control (p > 0.05) and it showed a tendency of less inflammatory response. This cement released more BO33− and SiO32−, but less Sr2+, Na+, and F− than other S-PRG specimens. Each cement recovered nearly neutral compared with glass ionomer cement. ConclusionsS-PRG cement induced tertiary dentin formation based on multiple ion releases, suggesting that it is suitable as a pulp capping material. Clinical relevanceThis new material can be an alternative pulp capping agent to MTA. |
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