不同剂量丙种球蛋白治疗儿童吉兰-巴雷综合征的疗效比较

目的观察不同剂量丙种球蛋白（IVIG）治疗儿童吉兰-巴雷综合征（GBS）的临床疗效。方法将符合GBS诊断的141例患者分为三组，分别给予不同剂量IVIG，并对疗效进行对比观察。结果三种给药方式对轻、中、重度患者的疗效差异无统计学意义（均P〉0．05），不同程度患者总有效率分别为95．83％、95．74％、82．85％。结论WIG治疗儿童吉兰-巴雷综合征具有良好的效果，低剂量组和大剂量组差异无统计学意义，低剂量WIG治疗儿童GBS亦有效。

Comparison of low dose and high dose human gamma globulin in therapy for acute Guillain-Barre syndrome in infants

Objective To observe the therapy effect of different dosages human gamma globulin （IVIG） for acute Guil- lain-Barre syndrome. Methods 134 cases of acute Guillain-Barre syndrome were divided into three groups. They were given different dosages of IVIG. Clinical effects were compared and observed. Results The curative effect of three kinds of drug ways for light, medium and severe patients had no significant differences （all P 〉 0.05）. The total effective rate of patients with different level was 95.83%, 95.74%, 82.85% respectively. Conclusion IVIG in the treatment of children with Guillain-Barre syndrome has a good effect. There is no significant difference between low dose and high dose human gamma globulin for acute Guillain-Barre syndrome. Low dosage IVIG in treating children with Guillain- Barre syndrome is also effective.