The distribution of anti-thyroglobulin antibodies in the immunoglobulin G subclasses

Using the coprecipitation technique with rabbit antisera specific for the human IgG subclasses, the antigen–binding capacity for thyroglobulin has been investigated in patients with Hashimoto''s disease. Anti-thyroglobulin activity was found in all four subclasses. The proportion of the total activity in each subclass closely paralleled the relative amounts of each subclass in normal serum.