抗结核药物致药物性肝损害影响因素分析

目的 探讨抗结核药物致药物性肝损害的影响因素.方法 对2003年3月-2006年3月本院门诊治疗的143例肺结核病人采用病例-对照方法进行回顾性分析.结果 抗结核药物致药物性肝损害的发生平均天数为57d,大多数为轻度肝细胞型.乙型病毒性肝炎是抗结核药物致肝功能损害的影响因素.结论 乙型病毒性肝炎是抗结核药物致药物性肝损害的危险因素,临床上应重视有乙型肝炎病史的肺结核病人,并短期密切检测肝功能.

Analysis of Affecting Factors in Drug-induced Liver Injury by Antituberculous Drugs

Objective To explore the affecting factors in durg-induced liver injury caused by the antituberculous drugs. Methods One hundred and forty-three cases of pulmonary tuberculosis outpatients after the treatment with antituberculous drugs from March 2003 to March 2006 were conducted a case-control prospective analysis.Result The drug-induced liver injury usually occurred during 57 days after the initiation of treatment by antituberculous drugs.Light hepatocllular type was the most frequent hepatoxic adverse effect.Hepatitis B virus infection was the risk factor of drug-induced liver injury ac- cording to the results of independent factor and multivariate logistic regression analysis.Conclusion Hepatitis B is an im- portant risk factor for drug-induced liver injury after antituberculous chemotherapy.More frequent regular liver function check up should be taken to the pulmonary tuberculosis patients who are complicated with hepatitis B.