枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停的疗效比较

目的 观察分析枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停的临床效果。方法 选取2014年6月-2015年6月经诊断为原发性呼吸暂停患儿80例为研究对象,按随机数字表法分为对照组40例和观察组40例,对照组给予常规护理配合氨茶碱注射液治疗;观察组给予常规护理配合枸橼酸咖啡因治疗。观察患儿的PCO₂、PaO₂检测值,患儿呼吸暂停的发作次数、发作时间、症状消除时间,并对治疗效果和不良反应进行观察分析。结果 治疗后两组PCO₂、PaO₂检测值均有所变,与治疗前比较差异有统计学意义(P<0.05);治疗后组间比较,观察组变化更显著(P<0.05);观察组患儿呼吸暂停次数、发作持续时间、症状消失时间均小于对照组,两组对比差异有统计学意义(P<0.05);观察组患儿治疗总有效率为75%,对照组为50%,差异有统计学意义(P<0.05);观察组不良反应为5%,对照组不良反应为20%,差异有统计学意义(P<0.05)。结论 枸橼酸咖啡因在治疗患儿呼吸暂停方面效果优于氨茶碱,且不良反应小,临床值得推广。

Comparison on clinical effects of caffeine citrate and aminophylline on premature infant with apnea

Objective To observe and analyze the clinical effect of caffeine citrate and aminophylline on premature infant with apnea. Methods Totally 80 cases of children diagnosed with primary apnea from June 2014 to June 2015 were chosen as the research object, then randomly divided into control group with 40 cases and observation group with 40 cases. The patients in control group were given routine nursing combined with aminophylline injection treatment; The patients in observation group were given routine nursing combining with caffeine citrate treatment. The readings of patient''s PCO₂ and PaO₂, the frequency of apnea, duration time of apnea symptoms, and relax time were observed, and the therapeutic effect and adverse reactions were analyzed. Results After treatment, the readings of PaCO₂ and PaO₂ in two groups both changed, the difference showed statistical significance compared with that before treatment (P<0.05); Comparison between groups after treatment, the changes in observation group were more obvious (P<0.05); the frequency of apnea, duration time of apnea symptoms and the relax time in observation group were less than those in control group, the difference showed statistical significance (P<0.05); The total effective rate in observation group reached 75% and that in the control group was 50%, the difference was statistically significant (P<0.05); The adverse reaction rate in observation group was 5%, and that in control reached 20%, the difference showed statistical significance (P<0.05). Conclusion The treatment of caffeine citrate on children with apnea shows a better effects with small adverse reactions, and is worthy of clinical spreading.