| 纳豆激酶分离纯化及体外溶栓和溶血作用研究 |
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| 引用本文： | 王萍,陈钧,陈红斌.纳豆激酶分离纯化及体外溶栓和溶血作用研究[J].中国药学杂志,2005,40(21):1669-1671. |
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| 作者姓名： | 王萍 陈钧 陈红斌 |
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| 作者单位： | 1. 江西农业大学动物科学技术学院,江西,南昌,330045;江苏大学生环学院制药工程系,江苏,镇江,212013
2. 江苏大学生环学院制药工程系,江苏,镇江,212013 |
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| 基金项目： | 江西省科技厅科技攻关项目 |
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| 摘 要： | 目的研究纳豆纤溶酶体外溶栓和溶血作用。方法体外溶栓和溶血实验方法。结果纳豆激酶粗酶(NKc)体外溶栓作用显著,高剂量(2836U)和低剂量(1418U)作用血凝块6h后,溶解率分别为88%和74%,蚓激酶(150000U)为87%;溶血实验结果表明,NKc有溶血作用。结论NKc有溶栓和溶血作用。
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| 关 键 词： | 纳豆激酶 体外溶枪 体外溶血 |
| 文章编号： | 1001-2494（2005）21-1669-04 |
| 收稿时间： | 2005-03-08 |
| 修稿时间： | 2005-03-08 |
Purification and its thrombolytic and hematolytic effect of nattokinase in vitro |
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| WANG Ping,CHEN Jun,CHEN Hong-bin.Purification and its thrombolytic and hematolytic effect of nattokinase in vitro[J].Chinese Pharmaceutical Journal,2005,40(21):1669-1671. |
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| Authors: | WANG Ping CHEN Jun CHEN Hong-bin |
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| Institution: | 1. College of Annimal Science And Tecnology, Jiangxi Agricultural University, Nanchang 330045, China;2. Department of Pharmacy, School of Biological and Enviromental Engineering, Jiangsu University, Zhenjiang 212013, China |
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| Abstract: | OBJECTIVE To study the thrombolytic and hematolytic effect of crude nattokinase in vitro. METHODS Thrombolytic and hemolytic experiment in vitro were conducted. RESULTS After 6h treatment with crude nattokinase at high dose (2836U) and low dose (1418U), respectively in vitro, 88% and 74% of thrombi were dissolved, respectively, and that of lumbrukinase was 87%. Crude nattokinase haemolyzed rabbit blood red cell. CONCLUSION Crude nattokinase owns thrombolytic and hematolytic function. |
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| Keywords: | nattokinase thrombolysis in vitro hemolysis in vitro |
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