Impact of prealbumin on mortality and hospital readmission in patients with acute heart failure |
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| Affiliation: | 1. Internal Medicine Service, Hospital Universitari Quiron Dexeus, Barcelona, Spain;2. Geriatric Care Unit, Internal Medicine Service, IDIBELL, Hospital Universitari de Bellvitge, L''Hospitalet de Llobregat, Barcelona, Spain;3. Internal Medicine Service, Hospital de Olot, Medical Sciences Department, Universitat de Girona, Girona, Spain;4. U.G.C, Internal medicine, Hospital Universitario Virgen Macarena, Sevilla. Spain;5. Internal Medicine Service, Hospital Universitario de Gran Canaria Dr.Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain;6. Internal Medicine Service, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Madrid, Spain;7. Internal Medicine Service, Hospital Costa del Sol, Malaga, Spain;8. Internal Medicine Service, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain;9. Internal Medicine Service, Hospital Universitario de Burgos, Burgos, Spain;10. Internal Medicine Service, IMIBIC/Hospital Universitario Reina Sofía, Universidad de Córdoba, Córdoba, Spain;2. Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China;3. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;4. Department of Cardiology, Tangshan People''s Hospital, North China University of Science and Technology, Tangshan, China;6. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China;5. Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China |
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| Abstract: | BackgroundPrealbumin is a maker of nutritional status and inflammation of potential prognostic value in acute heart failure (HF). The aim of this study is to evaluate if low prealbumin levels on admission predict mortality and readmissions in patients with acute HF.MethodWe conducted a prospective observational cohort study including 442 patients hospitalized for acute HF. Patients were classified in two groups according to prealbumin levels: “normal” prealbumin (> 15 mg) and “low” prealbumin (≤ 15 mg/dL). End-points were mortality and readmissions (all-cause and HF-related) and the combined end-point of mortality/readmission at 180 days.ResultsOut of 442 patients, 159 (36%) had low and 283 (64%) had normal prealbumin levels Mean age was 79.6 (73.9–84.2, p = 0,405) years and 183 (41%, p = 0,482) were males. After a median 180 days of follow-up, 108 (24%, p = 0,021) patients died and 170 (38%, p = 0,067) were readmitted. Mortality was higher in the low prealbumin group. The combined end-point was more frequent in the low prealbumin group (57% vs. 50%, p = 0.199). In the multivariate analysis the following variables were associated with mortality or readmission: older age, exacerbated chronic HF, higher comorbidity, low systolic blood pressure and hemoglobin values and higher pro brain natriuretic peptide levels.ConclusionsLow prealbumin is common (36%) in patients with acute heart failure and it is associated with a higher short-term mortality. |
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