香菇多糖联合化疗治疗晚期胃癌的疗效观察

目的 观察香菇多糖联合化疗综合治疗晚期胃癌的疗效和毒性.方法 115例晚期胃癌患者随机分为对照组57例和治疗组58例,对照组接受草酸铂(L-OHP)联合替加氟(FT-207)及亚叶酸钙(CF)化疗方案,治疗组接受L-OHP联合FT-207及CF化疗方案,配合香菇多糖及维生素B12、叶酸等综合治疗.结果 对照组PR 18例,总有效率为31.6%,中位疾病进展时间(TTP)为3.1个月,中位生存时间(MST)为5.5个月,1年、2年生存率分别为56.1%、22.8%;治疗组CR 1例,PR29例,总有效率为51.0%,中位疾病进展时间(TTP)为4.5个月,中位生存时间(MST)为9.8个月,1年、2年生存率分别为81.1%、51.7%,两组比较差异有统计学意义.两组毒性反应主要为骨髓抑制和消化道反应.血红蛋白下降、口腔黏膜炎发生率两组比较差异有统计学意义.结论 香菇多糖联合化疗综合治疗晚期胃癌的有效率高,毒性反应小,值得临床推广.

Clinical study of lentinan combination with chemotherapy in the synthetical treatment of advanced gastric cancer

Objective To study the curative effect and adverse drug reactions of lentinan combination with chemotherapy in the treatment of advanced gastric cancer.Methods 115 eases of advanced gastric cancer patients are divided to treatment group and control group randomly.57 pafients in control group ale treated with the chemotherapy rcglment:L-OHP combination with FT-207 and CF,58 patients in treatment group are treated with the chemotherapy regiment:L-OHP combination with FT-207 and CF,cooperating with the synthetical treatment with lenfinan and vitamin B12,folic acid and so on.Results The control group:there are 18 cases get PR,the total effective rate is 31.6%,TTP is 3.1 months,MST is 5.5 months,the rate of survival in first year and second years is 56.1%and 22.8% respectively.The treatment group:there are l case get CR and 29 cases get PR,the total effective rate is 51%,TTP is 4.5 months.MST iS 9.8 months,the rote of survival in first year and second years is 81.1%and 51.7%respectively.There is statistieall difference between these two groups(P＜0.05).The main adverse drug reactions of two groups are restraint of marrow and gastrointestinal reactions.there is statistical difiefence in the decrease of HbO2 and the rate of occurrence of buecal inflammation between these two groups.Conclusion The method of lentinan combination with chemotherapy in the synthetical treatment of advanced gastric cancer has high effective rate and small adverse drug reactions.It is worth of being popularized.