| 内皮素对肝血流量影响的实验研究 |
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| 引用本文： | 刘宝华,王代科.内皮素对肝血流量影响的实验研究[J].中国普外基础与临床杂志,1998,5(4):193-194. |
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| 作者姓名： | 刘宝华 王代科 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所 |
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| 摘 要： | 选用Ｗｉｓｔａｒ大鼠２０只，随机分为对照组、内皮素１（ＥＴ１）组、ＥＴ１＋硝基左旋精氨酸组和ＥＴ１＋前列环素＋消炎痛组，每组５只。采用氢气清除法观察ＥＴ１对肝血流量的影响以及一氧化氮（ＮＯ）和前列环素（ＰＧＩ２）对ＥＴ１生物学效应的调节作用。结果显示：ＥＴ１能使肝血流量迅速降低，并且持续时间较长；ＮＯ及ＰＧＩ２可部分拮抗ＥＴ１的生物学效应。表明内皮细胞源性血管因子对肝血流量有一定调节作用
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| 关 键 词： | 肝血流量 内皮素 一氧化氮 前列环素 |
EFFECT OF ENDOTHELIN 1 ON HEPATIC BLOOD FLOW IN RATS |
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| Liu Baohua,Wang Daike,Chen Huisun,et al..EFFECT OF ENDOTHELIN 1 ON HEPATIC BLOOD FLOW IN RATS[J].Chinese Journal of Bases and Clinics In General Surgery,1998,5(4):193-194. |
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| Authors: | Liu Baohua Wang Daike Chen Huisun |
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| Institution: | Liu Baohua,Wang Daike,Chen Huisun,et al. Department of General Surgery,Daping Hospital,The Research Institute of Surgery,Chongqing 400042 |
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| Abstract: | In order to study effect of endothelin (ET 1) on hepatic blood flow in rats and effect of nitric oxide (NO) and prostacyclin (PGI 2) on ET 1 biological function, 20 rats were randomized into control, ET 1, ET 1 plus nitric L arginine, ET 1 plus prostacyclin and indomethen groups. The result showed that ET 1 decreased hepatic blood flow and lasted for longer time. NO and PGI 2 may antagonize the biological action of ET 1 during endotoxemia. Therefore, the endothelium derived vascular factors may regulate hepatic blood flow. |
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| Keywords: | Hepatic blood flow Endothelin Nitric oxide Prostacyclin |
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