前S1抗原与乙肝病毒标志物关系的研究

目的 探讨HBV血清标志物与乙肝病毒前S1抗原（Pre-S1Ag）检测结果的关系。方法应用酶联免疫吸附试验法（ELISA）检测610患者的常规乙肝病毒血清标志物和乙肝病毒前S1抗原。结果本组HBsAg（＋）、HBeAg（＋）、抗-HBcAg（＋）血清样本226份，Pre-S1Ag阳性检出率为85．84％；HBsAg（＋）、HBeAg（＋）血清样本45份，Pre—S1Ag阳性检出率为93．33％；HBsAg（＋）、抗-HBeAg（＋）、抗-HBcAg（＋）血清样本298份，Pre—S1Ag阳性检出率为44．97％；HBsAg（＋）、抗-HBcAg（＋）血清样本41份，Pre—S1Ag阳性检出率为70．73％。HBeAg（＋）组Pre—S。Ag检出率为87．08％，HBeAg（-）组Pre—S1Ag检出率为35．80％，两者比较差异均具有统计学意义（P〈0．05）。抗-HBcAg（＋）组Pre·S1Ag检出率为64．50％，抗-HBcAg（-）组Pre-S1Ag检出率为82．55％，两者比较差异均具有统计学意义（P〈0．05）。结论Pre-S1Ag是HBV复制的可靠指标，与乙肝标志物联合检测可相互补充。

The Study on Relation of Hepatitis B virus Serum Markers and Pre-S1 Antigen

Objective To discuss relationship of hepatitis B virus gerum markers and Pre-S1 antigen.Methods Analyze the markers of HBV in blood serum and pre-S1 of HBV in 610 patients with ELISA.Results Pre-S1 antigen positive detection rate was 85.84% in 226 blood serum samples of HBsAg(+),HBeAg(+) and anti-HBcAg(+),Pre-S1 antigen positive detection rate was 93.33% in 45 blood serum samples of HBsAg(+) and anti-HBeAg(+).Pre-S1 antigen positive detection rate was 44.97% in 298 blood serum samples of HBsAg (+),anti-HBeAg(+) and anti-HBcAg(+).Pre-S1 antigen positive detection rate was 70.73% in 41 blood serum samples of HBsAg(+) and anti-HBcAg(+).The detection rate of Pre-S1 Ag was 87.08% in HBeAg(+) group and 35.80% in HBeAg(-) group,and there was significant difference between two groups(P＜0.05).The detection rate of Pre-S1Ag was 64.50% in anti-HBcAg(+) group and 82.55% in anti-HBcAg(-) group,and there was significant difference between two groups(P＜0.05).Conclusion Pre-S1Ag is a credible index of HBV replication,and may be helpful for HBV markers in detecting.