Modulation of T-cell-mediated regulation of antibody production by interaction with specific immune complexes |
| |
| Authors: | J D Clough L H Calabrese S A Budervic |
| |
| Affiliation: | Department of Rheumatic and Immunologic Disease, Cleveland Clinic Foundation, Ohio. |
| |
| Abstract: | The importance of the phlogogenic effects of immune complexes in disease pathogenesis has been emphasized, but they also have a role in immunoregulation. We examined the effects of DNA: anti-DNA immune complexes, formed at different antigen:antibody ratios, on the ability of T cells to modulate DNA antibody production in vitro. We found that antigen-excess complexes promote IgM anti-DNA synthesis, whereas antibody-excess complexes favor a switch to IgG anti-DNA production. We suggest that interaction of T cells with immune complexes is an important feedback mechanism in control of the immune response. |
| |
| Keywords: | |
|
|
