心肌酶谱检测在新生儿缺氧缺血性脑病中的应用

目的探讨新生儿缺氧缺血性脑病（Hypoxic-ischemic encephalopathy,HIE）血清心肌酶谱的变化及意义。方法采用速率法测定105例轻、中、重度新生儿HIE血清中谷草转氨酶（AST）、肌酸激酶（CK）、乳酸脱氢酶（LDH）、α-羟丁酸酶（α-HBDH）的浓度,评判HIE的病情。结果 HIE患儿血清AST、CK、LDH和α-HBDH浓度均显著高于正常对照组儿童（P〈0.05）;不同临床分组HIE患儿之间血清LDH、AST、CK和α-HBDH水平差异显著（P〈0.05）,且随着HIE病情加重,这几种酶的升高更明显（P〈0.05）。结论心肌酶谱对新生儿HIE的诊断及治疗有重要意义。

Clinical significance of the changes in myocardial enzymes in neonatal hypoxic ischemic encephalopathy

Objective To investigate variations of serum myocardial enzymes and their clinical value in newborns with hypoxic-ischemic encephalopathy (HIE).Methods Evaluated the clinical conditions in hypoxic ischemic encephalopathy by testing serum concentrations of AST, LDH, α-HBDH and CK in 105 cases of mild, moderate and severe hypoxic-ischemic encephalopathy,as well as 32 healthy newborns, with rate-method.Results Serum levels of AST,CK,LDH and α-HBDH increased significantly in neonatal hypoxic ischemic encephalopathy compared with normal newborns(P<0.05), and the enzymatic levels differed remarkably between the mild, the moderate and the severe(P<0.05); the more severe the condition was, the higher the concentrations of myocardial enzymes were in newborns with HIE.Conclusion Changes in myocardial enzymes play important roles in early diagnosis and treatment in neonatal hypoxic ischemic encephalopathy.