| MMP-9和TIMP-3在早孕先兆流产绒毛及蜕膜中的表达 |
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| 引用本文： | 李萍. MMP-9和TIMP-3在早孕先兆流产绒毛及蜕膜中的表达[J]. 泰山医学院学报, 2007, 28(2): 113-115 |
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| 作者姓名： | 李萍 |
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| 作者单位： | 泰山医学院附属医院,山东,泰安,271000 |
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| 摘 要： | 目的探讨基质金属蛋白酶-9(MMP-9)和基质金属蛋白酶组织抑制物-3(TIMP-3)在早孕先兆流产和正常早孕绒毛及蜕膜中的定位及表达,并分析其临床意义。方法应用免疫组织化学S-P法,检测正常早期妊娠和先兆流产行负压吸宫术者各30例的绒毛和蜕膜组织中MMP-9和TIMP-3的表达。结果MMP-9在先兆流产组绒毛和蜕膜中的表达均高于正常早孕组;TIMP-3在先兆流产组和对照组绒毛和蜕膜中的表达差异无统计学意义;MMP-9/TIMP-3的比值在先兆流产蜕膜和绒毛中的表达均高于正常妊娠组。结论MMP-9在早期流产发生过程中具有重要作用;MMP-9和TIMP-3的平衡对于正常早期妊娠的维持起重要作用。
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| 关 键 词： | 先兆流产 绒毛 蜕膜 |
| 文章编号： | 1004-7115（2007）02-0113-03 |
| 收稿时间： | 2006-12-20 |
| 修稿时间： | 2006-12-20 |
The expression of MMP-9 and TIMP-3 at the villus and deciduous of threatened abortion |
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| LI Ping. The expression of MMP-9 and TIMP-3 at the villus and deciduous of threatened abortion[J]. Journal of Taishan Medical College, 2007, 28(2): 113-115 |
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| Authors: | LI Ping |
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| Abstract: | Objective:To study the position and expresses of MMP9 and TIMP-3 at the villus and deciduous of the threatened abortion at early pregnancy;and the effect of MMP-9/TIMP-3 for sustaining the normal early pregnancy.Methods:Apply immunohistochemistry technology and computer image analysis systems to analysis the expression of MMP-9 and TIMP-3 in the villus and deciduous of early pregnancy abortion.Results:The expression of MMP-9 in the deciduous of the threatened abortion group is higher than the control group,the difference is significant(P<0.05).There is no significant difference in the two groups of the expression of of TIMP-3 in the deciduous and villus(P>0.05). Conclusion: The balance of MMP-9 and TIMP-3 play an important role for sustaining the normal early pregnancy. |
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| Keywords: | MMP-9 TIMP-3 |
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