| 海兰地嗪对大鼠主动脉条收缩的影响 |
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| 引用本文： | 徐平湘 孙颂三 郭景珍 尹钟洙 刘干中. 海兰地嗪对大鼠主动脉条收缩的影响[J]. 中药药理与临床, 1995, 11(5): 15-18 |
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| 作者姓名： | 徐平湘 孙颂三 郭景珍 尹钟洙 刘干中 |
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| 作者单位： | [1]首都医科大学药理教研室北京100054 [2]中日友好医院临床医学研究所药物药理室北京100029 |
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| 摘 要： | 海兰地嗪和维拉帕米使高K^ 及NE所致的大鼠离体主动脉条收缩张力下降，对高K^ 引起收缩的抑制作用强于对NE的扣制作用。两药明显抑制NE依赖内Ca^2 性收缩与外Ca^2 性收缩．使NE及Kcl所致大鼠主动脉条收缩的量一效曲线右移．最大效应降低。提示海兰地嗪阻滞钙离子通道与维拉帕米相似。
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| 关 键 词： | 海兰地嗪 大鼠 主动脉条收缩 维拉帕米 钙离子通道 |
Effect of the Hernandezine on Contraction of Rat Aortic Strips |
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| Xu pingxiang, Sun Sonhsan,. Effect of the Hernandezine on Contraction of Rat Aortic Strips[J]. Pharmacology and Clinics of Chinese Materia Medica, 1995, 11(5): 15-18 |
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| Authors: | Xu pingxiang Sun Sonhsan |
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| Abstract: | ernandezine (Her) and Verapamil (Ver) inhibited both the contractions of rat aortic strips evoked by high K and Nor-epinephrine (NE), the degree inhibited to high K was more potent than to NE.Both Her and Ver inhibitedthe fast contraction responses evoked by NE in Ca free medium and slow Ca -dependent component on contraction, caused the dose-response curves of NE and CaCL2 to shift rightward and depressed the maximal response. Thisshows that Her inhibited selectively potential-dependent Ca2 channel.The results indicate that Her like Ver, may bea new calcium antagonist. |
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| Keywords: | Hernandezine Verapamil Norepinephrine Aorta KCl |
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