Sublethal effects of pesticide mixtures on selected biomarkers of Carassius auratus |
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| Affiliation: | 1. Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environmental Science and Engineering, Hohai University, Nanjing 210098, People''s Republic of China;2. Environmental Monitor Station of Hangu District of Tianjin, Tianjin 300480, People''s Republic of China;1. Moldova Coordination Chemistry Department, Moldova State University, Chisinau, Republic of Moldova;2. Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw 02106, Poland;1. Department of Cell Biology, Federal University of Paraná, Centro Politécnico s/No, Curitiba, PR 81.530-130, Brazil;2. Basic Bioscience Institute, University of Taubaté, Av. Tiradentes, 500-Centro, Taubaté, SP 12030-180, Brazil;3. Department of Marine Biology, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373-CCS-Bloco A-Sala 89, Rio de Janeiro, RJ 21941-902, Brazil;1. Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, Brescia, Italy;2. Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy;3. Department of Nuclear Medicine, Ospedali Galliera, Genoa, Italy;4. Department of Radiology, Spedali Civili di Brescia, Brescia, Italy;5. Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland;1. Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan, Republic of China;2. Institute of Physiology, National Cheng Kung University, Tainan, Taiwan, Republic of China |
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| Abstract: | In the present study, the in vivo effects of commercial propoxur alone and in combination with isoprocarb and chlorpyrifos on acetylcholinesterase and glutathione S-transferases activities in goldfish (Carassius auratus) were investigated. Brain and muscle AChE activity was significantly inhibited (88% and 85% at most, respectively) by propoxur after 5 d of exposure at concentrations between 141 and 2263 μg/L, bell-shaped concentration–response curves were obtained. In most cases, time dependence was apparent. Under insecticide mixture exposure (binary mixture propoxur/isoprocarb and ternary mixture propoxur/isoprocarb/chlorpyrifos), the inhibition of AChE activity was significant in all cases and linear concentration–response relationships were observed. Propoxur (alone and in combination) significantly inhibited gill GST activity, and both mixtures also induced significant inhibition of liver GST activity. However, concentration and time dependence were not apparent. AChE is likely to be more informative than GST and seems to be a good biomarker to diagnose exposure to anticholinesterase pesticides in wild populations of this species. |
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