Rs4948496 within ARID5B gene is associated with clinical features of systemic lupus erythematosus in the Chinese Han population |
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| Authors: | Long Jiang Jianping Wu Weiran Li Juan Du Wenjun Wang Zhengwei Zhu Jinping Gao Yujun Sheng Xianyong Yin Xiaodong Zheng Hui Li Yang Li Li Meng Xing Fan Shengxiu Liu Ming Zeng Zaixing Wang Yong Cui Huayang Tang Liangdan Sun Sen Yang Xuejun Zhang |
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| Affiliation: | 1. Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China;2. Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China |
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| Abstract: | In our previous meta‐analysis of genome‐wide association study, we identified the single nucleotide polymorphism (SNP) rs4948496 (P = 5.1 × 10?11, odds ratio [OR] = 0.85) within the ARID5B gene associated with systemic lupus erythematosus (SLE) in a Chinese population. To investigate its association with disease subphenotypes, we further analyzed the genotype data of rs4948496 in 4348 cases and 6679 controls from our previous meta‐analysis and an independent replication cohort in this study. The SNP rs4948496 was significantly associated with SLE (P = 1.61 × 10?5, OR = 0.88, 95% confidence interval [CI] = 0.83–0.93) in our group. In case‐only study, the genotype of rs4948496 was associated with antinuclear antibodies (P = 0.03, OR = 0.81, 95% CI = 0.68–0.98) and anti‐RNP (P = 0.03, OR = 0.86, 95% CI = 0.76–0.99). This study showed that rs4948496 in ARID5B is associated with several subphenotypes of SLE and this gene may cause the complicacy of clinical features. |
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| Keywords: | genotype phenotype single nucleotide polymorphism susceptibility gene systemic lupus erythematosus |
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