Inhibition of platelet aggregation by an irreversible local anesthetic |
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Authors: | J F Stubbins C Pearson G D Qureshi |
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Affiliation: | Department of Medicinal Chemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond. |
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Abstract: | Three known local anesthetic agents were examined for their ability to inhibit platelet aggregation induced by adenosine diphosphate or epinephrine. Drug-treated platelet-rich plasma samples were filtered through agarose gel to remove free drug, and the ability of the platelets to aggregate was again determined. One of the local anesthetics contained a "one-armed" nitrogen mustard structure and appeared to produce an irreversible inhibition of aggregation. The other two agents gave a block of aggregation that was reversed upon gel filtration. |
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