质子泵抑制剂对老年溃疡病人胃内酸度的影响

观察质子泵抑制剂对老年消化性溃疡病人胃内酸度的影响。对经内镜证实的老年溃疡病２０例。非老年溃疡病１２例，测定其２４ｈ胃同ＰＨ节律。分别测定治疗前及服质子泵抑制剂７天时２４ｈ胃内ＰＨ动态变化。结果老年溃疡病人服药前，２４ｈ ｐＨ〉４的总时间百分比，中位ＰＨ，平均ＰＨ，分别为０．０３，１．３４、１．９２；

EFFECT OF PROTON PUMP LNHIBITOR ON LNTRAGASTRIC ACIDITY IN ELDERLY PATIENTS WITH PEPTIC ULCER

To observe the effect of proton pump inhibitor on gastric acidity in elderly patients with peptic ulcer, the circadian pattern of 24 hour intragastric pH was analyzed in 32 patients with peptic ulcer before and after medication by 24 hour pH monitoring. Before medication, percentage of total time with pH>4 during 24 hour median pH and mean pH in elderly group were 0.063, 1.34 and 1.92, respectively. Seven days after the treatment with proton pump inhibitor, percentage of total time with pH>4, median pH and mean pH were 0.882, 6.68 and 6.45, respectively. The differences were highly significant ( P <0.01). Compared elderly patients with non elderly patients, no significant difference was found in pH parameters before and after medication.The values of percentage of total time with pH<4 and 24 hour median pH were simiar between elderly and non elderly groups. Proton pump imhibitor is effieaciour in the treatment of peptic ulcer through raising the level of intragastric pH.