Norepinephrine regulates long-term potentiation of both the population spike and dendritic EPSP in hippocampal dentate gyrus |
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| Authors: | P K Stanton J M Sarvey |
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| Affiliation: | 1. Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China;2. Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China;3. Department of Anesthesiology, University of Florida, Gainesville, FL, USA;4. McKnight Brain Institute, University of Florida, Gainesville, FL, USA |
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| Abstract: | Hippocampal slices from norepinephrine (NE)-depleted rats exhibited marked reductions in long-term potentiation (LTP) of both the population spike and dendritic EPSP in the dentate gyrus. In contrast, depletion of serotonin (5-hydroxytryptamine, 5-HT) had no effect on either population spike or EPSP-LTP. In addition, superfusion of slices with NE produced potentiation of both the granule cell population spike and dendritic EPSP which persisted long after NE washout. These data support a role for NE in regulating long-term plasticity of both granule cell action potential firing and dendritic EPSPs. |
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