| 蜈蚣对心肌缺血性损伤小鼠NO及iNOS的影响 |
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| 引用本文： | 司秋菊,王亚利,王鑫国,白霞. 蜈蚣对心肌缺血性损伤小鼠NO及iNOS的影响[J]. 山东中医杂志, 2004, 23(8): 492-494 |
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| 作者姓名： | 司秋菊 王亚利 王鑫国 白霞 |
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| 作者单位： | 1. 河北医科大学中西医结合学院,河北,石家庄,050091
2. 河北医科大学中医学院,河北,石家庄,050091 |
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| 基金项目： | 河北省自然基金委员会资助项目 ( NO.3 972 74) |
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| 摘 要： | 目的 :探讨中药蜈蚣对心肌缺血性损伤小鼠一氧化氮 (NO)及一氧化氮合酶 (i NOS)的影响。方法 :采用脑垂体后叶素造成小鼠心肌缺血性损伤模型。将健康小鼠分为四组 ,分别是空白组、模型组、蜈蚣小剂量组(2 .5 g/ kg)、蜈蚣大剂量组 (5 .0 g/ kg)。缺血 2 0 m in后取血观察乳酸脱氢酶 (L DH ) ,检测心肌组织一氧化氮 (NO) ,免疫组化法检测心肌一氧化氮合酶 (i NOS)。结果 :蜈蚣治疗后 L DH降低 ,NO、i NOS明显升高。结论 :蜈蚣可显著提高 NO及 i NOS的表达 ,这可能与蜈蚣保护血管内皮细胞功能有关。
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| 关 键 词： | 蜈蚣 心肌缺血 一氧化氮 一氧化氮合酶 |
| 文章编号： | 0257-358X(2004)08-0492-03 |
| 修稿时间： | 2003-12-31 |
Effects of centipede on nitric oxide and nitric oxide synthase in mice after myocardial injury |
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| SI Qiu-ju,WANG Ya-li,WANG Xin-guo,BAI Xia. Effects of centipede on nitric oxide and nitric oxide synthase in mice after myocardial injury[J]. Shandong Journal of Traditional Chinese Medicine, 2004, 23(8): 492-494 |
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| Authors: | SI Qiu-ju WANG Ya-li WANG Xin-guo BAI Xia |
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| Affiliation: | SI Qiu-ju1,WANG Ya-li2,WANG Xin-guo2,BAI Xia2 |
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| Abstract: | Objective:To explore the effects of centipede on nitric oxide (NO) and iNOS in mice after myocardial injury.Method:Myocardial ischemia models were established by pituitrin.Micewere randomly divided into four groups,the control group,model group,small dose centipede group(2.5 g/kg)and big dose centipede group(5 g/kg).Every group had ten mice.After 20 minutes,myocardial ischemia mice's LDH and NO were observed.iNOS was determined by immunohistochemical assay.Results:After centipede treatment,LDH decreased.NO and iNOS expression increased.Conclusion:Centipede could significantly increased NO and iNOS expression.It may be related to centipede protect vascular endothelial cells. |
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| Keywords: | centipede myocardial ischemia nitric oxide nitric oxide synthase |
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