| VEGF、COX-2 mRNA在食管癌中的表达及其意义 |
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| 引用本文： | 廉建红,王春利,王国平,王思萌,刘维兰,郭素堂. VEGF、COX-2 mRNA在食管癌中的表达及其意义[J]. 肿瘤研究与临床, 2008, 20(7): 454 |
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| 作者姓名： | 廉建红 王春利 王国平 王思萌 刘维兰 郭素堂 |
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| 作者单位： | 1. 山西省肿瘤医院胸外科,太原,030013
2. 山西省肿瘤研究所分子生物室 |
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| 摘 要： | 目的 探讨血管内皮生长因子(VEGF)剪接变异体、环氧合酶-2(COX-2)与食管癌发生的关系.方法 应用RT-PCR方法对40例食管癌组织及其相应癌旁组织中VEGF、COX-2 mRNA的表达进行了研究.结果 VEGF121mRNA在癌组织中及相应癌旁组织中均有表达,两组差异无统计学意义.40例癌组织中,VEGF165高表达25例,占62.5%;COX-2高表达28例,占70%;40例癌旁组织中,VEGF165高表达6例(15.0%);COX2高表达5例(12.5%).结论 VEGF165、COX-2与食管癌的发生密切相关.
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| 关 键 词： | 食管肿瘤 血管内皮生长因子类 环氧化酶2 |
| 收稿时间： | 2007-11-29 |
Expression of VEGF, COX-2 mRNA in esophageal cancer |
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| LIAN Jian-hong,WANG Chun-li,WANG Guo-ping,WANG Si-meng,LIU Wei-lan,GUO Su-tang. Expression of VEGF, COX-2 mRNA in esophageal cancer[J]. Cancer Research and Clinic, 2008, 20(7): 454 |
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| Authors: | LIAN Jian-hong WANG Chun-li WANG Guo-ping WANG Si-meng LIU Wei-lan GUO Su-tang |
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| Affiliation: | LIAN Jian-hong[1] WANG Chun-li[1] WANG Guo-ping[2] WANG Si-meng[2] LIU Wei-lan[2] GUO Su-tang[2] |
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| Abstract: | Objective To study the expression of VEGF isoforms, COX-2 in esophageal cancer Methods VEGF, COX-2 mRNA expression in 40 paired samples (tumor and adjacent normal tissue) were determined by using real time RT-PCR. Results VEGF165 was overexpressed in 25 of 40(62.5 %) tumor tissues compared with in 6 of 40 (15 %) adjacent normal tissue; COX-2 was overexpressed in 28 of 40(70 %) tumor tissues compared with in 5 of 40(12.5 %) adjacent normal tissue. Conclusion This result suggests that VEGF165 and COX-2 overexpression in esophageal cancer. |
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| Keywords: | Esophageal neoplasms Vascular endothelial growth factors Cyclooxygenase 2 |
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